The selection of braking pancreatic enzyme ending in the intraduodenal amylase introduction.

Abstract

The removal of pancreatic juice from the duodenum increases the secretion of the pancreas, and the reverse introduction of juice inhibits it. The mechanism of this effect has been the subject of lively discussion for many years. The study of this issue is not only theoretical, but also of practical importance, including for improving the methods of functional diagnostics and replacement enzyme therapy. Thus, based on the accumulated data, it can be assumed that during continuous aspiration of the pancreatic juice probe from the duodenum, the hypersecretory reaction of the gland appears if secretion is caused by the introduction of a stimulant (eg hydrochloric acid) and is absent if it is caused by parenteral administration of secretin with pancreasimine. Most researchers have an effect of inhibition of secretion associated with the action of trypsinogen or its hexapeptitic fragment on the endocrine apparatus of the duodenum. However, it is said that oral administration of amylase reduces the amylolytic activity of rat pancreatic homogenate