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Title: Endothelial function, regulation of angiogenesis and embryonic central hemodynamics in ART-conceived pregnancies
Authors: Bashmakova, N. V.
Tsyvian, P. B.
Chistiakova, G. N.
Gazieva, I. A.
Trapeznikova, Y. M.
Mazurov, D. O.
Issue Date: 2015
Publisher: Mother and Child Care Research Institute
Citation: Bashmakova N. V., Tsyvian P. B., Chistiakova G. N., Gazieva I. A., Trapeznikova Y. M., Mazurov D. O. Endothelial function, regulation of angiogenesis and embryonic central hemodynamics in ART-conceived pregnancies. Gynecological Endocrinology, 2015. pp. 1-3.
Abstract: This study was undertaken to compare the concentrations of pro- and anti-angiogenic growth factors, nitric oxide (NO) stable metabolites in maternal serum and embryonic left ventricular (LV) isovolumic relaxation time (IRT, ms) during the first trimester in two groups of women: with pregnancy conceived by assisted reproductive technologies (ART, nј39) and normally conceived (control group, nј68) pregnancy. The concentration of vasoconstrictor endothelin 1 was 45.5 times more in ART than in control group. On the contrary, the concentrations of NO stable metabolites in ART were 1.9 times less than in control women. The assessment of angiogenic suppressors in ART women demonstrates the decrease in s-endoglin concentration was 1.6 times and in soluble receptor to vascular endothelial growth factor concentration was 2.0 times in comparison with control group. There was a significant increase in LV IRT in ART embryos in comparison to control ones. These data suggest significant changes in pro-antiangiogenic factors balance and increase in vascular impedance in ART-conceived embryos.
Origin: Gynecological Endocrinology, 2015
Appears in Collections:Публикации в журналах, альманахах

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