Сравнительная характеристика иммунологических показателей индуцированной мокроты у детей с бронхиальной астмой легкой степени тяжести

Abstract

Authors investigate immunologic factors of induced sputum in children with mild asthma. The aim of the study was to find out the differences of immunologic profiles in intermittent and persistent mild asthma. 57 children aged 6-18 years old (12±0,45) with diagnosed stable mild asthma (41 (72%) - with intermittent and 16 (28%) - with persistent mild asthma) were include in this study. Control group was 10 children without allergic diseases, which had no respiratory symptoms during last month. Sputum induction carried out according to our modification of protocol developed by Pin et al. The levels of IgE, slgA, lgMy IgG, IL-4, IL-8, TNFα, INFγ, NO were evaluated in sputum. Results. The levels of proinflammatory factors in sputum were elevated in both forms of mild asthma. But the levels of IL-4, IL-8, NO were significantly higher in sputum of children with intermittent asthma, than in persistent mild asthma (p<0,05). We can conclude, that chronic inflammation already exists in intermittent mild asthma and this group of patients needs in administration of controller medications.