Клинико-экспериментальные сопоставления при фетальном алкогольном синдроме

Abstract

The adverse effects of alcohol on the developing human represent a spectrum of structural anomalies and behavioral and neurocognitive disabilities, most accurately termed fetal alcohol spectrum disorders (FASD). In animal models of FASD, ethanol causes a number of changes in brain development, with many of these changes being very transient. In the same number it is necessary to carry experimental works: to estimate intra-uterine influence of alcohol on development structures of the central excitatory system at experimental animals. Researches on rats of line Vistar. Anim als received instead of water within a month up to pregnancy and during all pregnancy of 15 % a solution of spirit. From the received posterity in the age of one month for optical research took a brain of a bark of a touch zone, hypothalamic areas and a cerebellum. Except for that for 9-12 day of pregnancy defined a level of the transforming factor of growth beta one (TGF-β1) at animals of the given experiment. At animals developmental anomalies of eyes, ears, and skulls were observed. The expressed changes have been found. Dystrophic changes neurons have been expressed. Comparing obtained data with parameters TGF- β1, we had noted been increase of concentration in skilled group. Thus, revealed features TGF- β1 are comparable to morphological changes in a brain, can be conditionally connected on sim ilar by the processes, arising mammals and the person.

Данная статья посвящена клинико-экспериметальным сопоставлениям антенатального воздействия алкоголя на центральную нервную систему развивающегося организма ребенка. С этой целью нами проведен эксперимент на крысах стадного разведения линии Вистар, алкоголизированных в течение месяца до беременности и во время беременности. У полученного потомства в возрасте одного месяца для светооптического исследования брали головной мозг. Также проанализирован уровень трансформирующего фактора роста 01 (TGF- β1) у животных во время беременности с использованием метода гетерогенного твердофазного иммуноферментного анализа.